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COVID mRNA Vaccine: Facts on the Intramuscular Injection

July 5, 2023
A medical illustration of an individual receiving the Covid mRNA Vaccine via the upper arm muscle ( intramuscular injection method )
A medical illustration of an individual receiving the Covid mRNA Vaccine via the upper arm muscle ( intramuscular injection method )


In the midst of the unprecedented COVID-19 pandemic, scientific breakthroughs have paved the way for the development of effective vaccines. Among them, the mRNA vaccines have emerged as game-changers, offering hope and a potential end to the global crisis. In this blog, we'll delve into the fascinating facts and numbers surrounding the COVID mRNA vaccine, shedding light on its remarkable journey and impact.

The mRNA Revolution

The mRNA (messenger RNA) vaccines represent a groundbreaking technology that harnesses the power of genetic information. Unlike traditional vaccines that introduce weakened or inactivated viruses, mRNA vaccines utilize a small piece of the virus's genetic code, namely the spike protein, to trigger an immune response. This innovation allows for faster vaccine development and adaptation to new variants, making mRNA vaccines highly versatile and responsive.

medical illustration Showcasing an artistic representation of an mRNA strand inside a cell, with ribosomes translating the mRNA and assembling spike proteins on the cell surface
An mRNA strand inside a cell, with ribosomes translating the mRNA and assembling spike proteins on the cell surface

Lightning-Fast Development

The development of COVID mRNA vaccines, such as the Pfizer-BioNTech and Moderna vaccines, astonished the world with their speed. Within a remarkable timeframe, these vaccines went from the identification of the virus's genetic sequence to large-scale clinical trials and authorization. The unprecedented collaboration between scientists, pharmaceutical companies, and regulatory bodies expedited the process while maintaining rigorous safety and efficacy standards.

Stellar Efficacy Rates

Clinical trials have demonstrated the remarkable efficacy of mRNA vaccines against COVID-19. Both Pfizer-BioNTech and Moderna vaccines achieved efficacy rates above 90%, surpassing expectations. These numbers signify that vaccinated individuals are significantly less likely to contract severe illness, hospitalization, or death caused by COVID-19. The mRNA technology's ability to elicit a robust immune response has proven its worth in the fight against the virus.

Global Vaccination Campaign

Since the mRNA vaccines received emergency use authorizations, a vast global vaccination campaign has been underway. According to the World Health Organization (WHO), as of July 2023, over 3.5 billion vaccine doses have been administered worldwide, with mRNA vaccines playing a crucial role. This massive effort has brought relief to countless individuals and communities, curbing the spread of the virus and reducing its impact on healthcare systems.

Adverse Reactions: Rare and Manageable

As with any medical intervention, mRNA vaccines may cause side effects. However, adverse reactions to COVID mRNA vaccines are generally mild and transient. The most commonly reported side effects include pain at the injection site, fatigue, headache, and muscle pain. Serious adverse events are rare, and the benefits of vaccination far outweigh the risks. The monitoring systems in place ensure the continuous evaluation of vaccine safety.

The SARS-CoV-2 is an enveloped, single-stranded RNA virus. It has a spherical or pleomorphic shape and possesses a distinct crown-like appearance under an electron microscope.
The SARS-CoV-2 is an enveloped, single-stranded RNA virus.

Real-World Effectiveness

Beyond clinical trials, real-world data has provided further insights into the effectiveness of mRNA vaccines. Numerous studies have shown that fully vaccinated individuals have a significantly reduced risk of infection, transmission, and severe illness, even against emerging variants. These findings reinforce the importance of widespread vaccination to protect individuals and communities, fostering hope for a return to normalcy.

Variants and Boosters

The mRNA vaccines' adaptability is crucial in the face of emerging variants. As new variants of the virus emerge, researchers and manufacturers can swiftly modify the mRNA vaccine's genetic sequence to target the specific spike protein variant. Booster shots tailored to these variants can enhance immunity and extend the protection offered by the initial vaccination, contributing to long-term control of the pandemic.


The advent of mRNA vaccines has revolutionized the world's approach to combating infectious diseases, offering an effective and adaptable solution to the COVID-19 crisis. With remarkable efficacy rates, global vaccination campaigns, and ongoing research on variants and boosters, the COVID mRNA vaccines have undoubtedly reshaped the landscape of public health. As we continue to navigate this pandemic, it is crucial to stay informed, trust in scientific advancements, and collectively work towards a brighter, healthier future.


  1. Moderna. (n.d.). How mRNA Vaccines Work. Retrieved from
  2. Krammer, F. (2020). SARS-CoV-2 vaccines in development. Nature, 586(7830), 516-527. doi: 10.1038/s41586-020-2798-3
  3. Polack, F. P., Thomas, S. J., Kitchin, N., Absalon, J., Gurtman, A., Lockhart, S.,... Gruber, W. C. (2020). Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. New England Journal of Medicine, 383(27), 2603-2615. doi: 10.1056/NEJMoa2034577
  4. World Health Organization (WHO). (2023). Coronavirus disease (COVID-19) pandemic. Retrieved from
  5. Centers for Disease Control and Prevention (CDC). (2021). COVID-19 Vaccines: Safety. Retrieved from
  6. Hall, V. J., Foulkes, S., Saei, A., Andrews, N., Oguti, B., Charlett, A.,... Lopez-Bernal, J. (2021). Effectiveness of BNT162b2 mRNA vaccine against infection and COVID-19 vaccine coverage in healthcare workers in England, multicentre prospective cohort study (the SIREN study). The Lancet, 397(10286), 1725-1735. doi: 10.1016/S0140-6736(21)00790-X
  7. World Health Organization (WHO). (2021). COVID-19 Variants. Retrieved from

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The medical visualizations showcased by Ghost Medical are intended solely to demonstrate our portfolio work and are not intended to be labeled as reliable FDA claims in the healthcare market. Surgeons and healthcare professionals should exercise caution and conduct their own research before relying solely on the information presented in the visualizations. Please be aware that while our work strive to accurately represent medical concepts and technologies, they may not always reflect the current state of the medical industry.
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