Welcome to this exciting journey into the world of groundbreaking technology—the SOMA Scan assay. In this informative video visualized by Ghost Medical Animation for Somalogic, we will delve into the innovative SOMAmers reagents and the extraordinary specificity they bring to protein measurement.
With over 7,000 proteins and counting, scientists and researchers face a daunting task—measuring all these proteins simultaneously. But how do they achieve such a feat? The answer lies in the realm of exquisite specificity.
In the vast realm of biology, interactions between complementary shapes play a crucial role. Proteins, with their diverse shapes and sizes, require affinity reagents for accurate measurement. Traditionally, polyclonal antibodies have been widely used, but they often lack specificity. Enter SOMAmers reagents—a new class of reagents that is revolutionizing protein measurement.
SOMAmers reagents are custom-made to target each protein of interest. They utilize modified side chains that enhance shape complementarity with their targets. Unlike antibodies, these reagents offer consistent performance across different batches. Through an extensive library of candidate sequences, a million billion molecules are screened until the perfect shape match is found.
To further enhance specificity, multiple SOMAmers reagents are used per protein. This sets them apart from antibody-based assays, which require two polyclonal antibodies and can have cross-reactivity issues. Binding affinity is not the only consideration—SOMAmers reagents are selected for their slow off rates, ensuring that the correct protein remains preferentially bound.
SOMA Logic has developed the groundbreaking SOMA Scan assay, a two-step process that enables the measurement of over 7,000 proteins simultaneously, each with a high degree of specificity. This assay incorporates a universal polyanionic competitor, preventing re-binding after rapid disassociation. Unlike antibody-based assays, the universal competitor is highly effective due to the consistency of Soma Marie reagents' interaction with proteins.
The SOMA Scan assay combines several cooperative mechanisms to achieve its exceptional specificity. Firstly, SOMAmers reagents are chemically synthesized with modified side chains, eliminating the need for a second affinity reagent. Secondly, each reagent is meticulously matched to its target protein based on perfect binding shape and slow off rates. Finally, the two-catch design of the assay utilizes a universal competitor, minimizing non-specific protein binding.
Why settle for underperforming antibody assays when you can trust the SOMA Scan assay? Experience the power of exquisite specificity in protein measurement with this innovative technology.
If you're eager to dive deeper into Somalogic and the SOMA Scan assay, visit their official website
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