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DiFUSION discusses ZFUZE™ at NASS 2023

DiFUSION Discusses ZFUZE™ at NASS 2023

Ghost Medical Animation + VR Surgery
November 14, 2023
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In a groundbreaking interview conducted by at the NASS 2023 conference, Sriram Sankar, MS Director of Research & Development at DiFUSION Technologies Inc., unveiled the revolutionary ZFUZE technology. This composite polymer is poised to redefine the landscape of medical implants, particularly in the field of orthopedics and spine healthcare. In this blog post, we'll delve into the key takeaways from the interview and explore how ZFUZE is transforming the world of medical implants.

The Quest for Ideal Implant Materials

Sankar began the interview by addressing a longstanding challenge in orthopedics - finding the perfect implant material. Traditional materials like poly ketone (PEEK) and titanium have been used for spinal devices, but each has its limitations. PEEK possesses mechanical properties similar to bone but lacks bone-friendly characteristics, while titanium, while bone-friendly, presents stiffness and imaging challenges. The quest has always been to find a material that combines the best of both worlds.

Introducing ZFUZE

DiFUSION Technologies Inc. has taken on this challenge head-on with its groundbreaking ZFUZE technology. ZFUZE is a composite polymer derived from PEEK and negatively charged ceramic aluminum silicate molecules. This hydrophilic load-bearing medical polymer allows for bony ingrowth into the implant while retaining the visualization, modulus, and strength benefits of PEEK.

Positive Immune Response

One of the most remarkable aspects of ZFUZE is its ability to elicit a positive immune response. Research by Dr. Stephen Badylak at the McGowan Institute for Regenerative Medicine confirmed that ZFUZE consistently shifts the M1 to M2 macrophage phenotype, typically occurring at Day 4-5. This immune response is crucial for normal tissue regeneration and prevents the fibrous encapsulation often observed with other implants.

Quicker Recovery Times

The advantages of ZFUZE extend to patients' recovery times. Sankar revealed that patients undergoing lumbar fusion or cervical fusion with ZFUZE experience significantly shorter recovery timelines. In traditional cases, healing might take 10 months to a year, but with ZFUZE, this period is reduced to about seven or eight months. Even patients with osteopenia or comorbidities have shown improved healing rates with ZFUZE.

Future Innovations

DiFUSION Technologies Inc. is not resting on its laurels. They are actively working on enhancing ZFUZE further. The next generation of this material aims to incorporate therapeutic metal ions such as calcium, magnesium, and zinc, known to support bone growth. This innovation holds the promise of opening up new possibilities for various medical applications.

Company Background

Founded in 2009, DiFUSION Technologies Inc. has dedicated the past seven to eight years to the development of ZFUZE. The company's headquarters and production facility are located in Austin, Texas. While their current focus is on spinal implants, they are also exploring opportunities in the premium maxillofacial trauma and dental spaces.


The interview with Sriram Sankar of DiFUSION Technologies Inc. at NASS 2023 has shed light on the groundbreaking potential of ZFUZE technology in the world of medical implants. By addressing the limitations of traditional materials, ZFUZE offers a unique combination of benefits, including a positive immune response and quicker patient recovery times. With ongoing research and innovations on the horizon, DiFUSION is poised to make a significant impact in the orthopedic and spine healthcare industry, ultimately improving the lives of patients around the world. Stay tuned for more updates on this game-changing technology.

DiFUSION discusses ZFUZE™ at NASS 2023 -

November 13, 2023
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